Insulin Therapy and Hypoglycemia

Insulin Therapy and Hypoglycemia - Present and Future

Kidney Injury, Insulin Therapy, and Hypoglycemia

The intent of this review is to evaluate the literature with respect to increased risk for hypoglycemia for critically ill patients with acute kidney injury or chronic kidney disease who are given insulin therapy. The unique pathophysiology of insulin and glucose metabolism during renal failure that predisposes patients for hypoglycemia is reviewed. Studies that contribute to the understanding ...

A glucose-responsive insulin therapy protects animals against hypoglycemia.

Hypoglycemia is commonly associated with insulin therapy, limiting both its safety and efficacy. The concept of modifying insulin to render its glucose-responsive release from an injection depot (of an insulin complexed exogenously with a recombinant lectin) was proposed approximately 4 decades ago but has been challenging to achieve. Data presented here demonstrate that mannosylated insulin an...

Insulin Pump Therapy With Automated Insulin Suspension in Response to Hypoglycemia

OBJECTIVE To evaluate a sensor-augmented insulin pump with a low glucose suspend (LGS) feature that automatically suspends basal insulin delivery for up to 2 h in response to sensor-detected hypoglycemia. RESEARCH DESIGN AND METHODS The LGS feature of the Paradigm Veo insulin pump (Medtronic, Inc., Northridge, CA) was tested for 3 weeks in 31 adults with type 1 diabetes. RESULTS There were ...

Preabsorptive insulin release and hypoglycemia in rats.

Peripheral blood glucose and immunologically reactive insulin levels were determined in freely moving normal rats which were submitted either to a free oral glucose load or to a gastric administration of the glucose load. Identical determinations were performed in ventromedial hypothalamic nucleus-(VMH) lesioned and vagotomized rats after the same oral intake. It was demonstrated that: 1) a fre...